Multi-grid finite element method used for enhancing the reconstruction accuracy in Cerenkov luminescence tomography

Hongbo Guo; Xiaowei He; Muhan Liu; Zeyu Zhang; Zhenhua Hu; Jie Tian

doi:10.1117/12.2252057

9 March 2017 Multi-grid finite element method used for enhancing the reconstruction accuracy in Cerenkov luminescence tomography

Hongbo Guo, Xiaowei He, Muhan Liu, Zeyu Zhang, Zhenhua Hu, Jie Tian

Author Affiliations +

Proceedings Volume 10132, Medical Imaging 2017: Physics of Medical Imaging; 101324I (2017) https://doi.org/10.1117/12.2252057
Event: SPIE Medical Imaging, 2017, Orlando, Florida, United States

Abstract

Cerenkov luminescence tomography (CLT), as a promising optical molecular imaging modality, can be applied to cancer diagnostic and therapeutic. Most researches about CLT reconstruction are based on the finite element method (FEM) framework. However, the quality of FEM mesh grid is still a vital factor to restrict the accuracy of the CLT reconstruction result. In this paper, we proposed a multi-grid finite element method framework, which was able to improve the accuracy of reconstruction. Meanwhile, the multilevel scheme adaptive algebraic reconstruction technique (MLS-AART) based on a modified iterative algorithm was applied to improve the reconstruction accuracy. In numerical simulation experiments, the feasibility of our proposed method were evaluated. Results showed that the multi-grid strategy could obtain 3D spatial information of Cerenkov source more accurately compared with the traditional single-grid FEM.

Citation Download Citation

Hongbo Guo, Xiaowei He, Muhan Liu, Zeyu Zhang, Zhenhua Hu, and Jie Tian "Multi-grid finite element method used for enhancing the reconstruction accuracy in Cerenkov luminescence tomography", Proc. SPIE 10132, Medical Imaging 2017: Physics of Medical Imaging, 101324I (9 March 2017); https://doi.org/10.1117/12.2252057

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