Photodynamic diagnosis and related optical techniques for the management of malignant glioma

R. Sroka; H. Stepp; W. Beyer; N. Markwardt; A. Rühm

doi:10.1117/12.2270006

29 April 2017 Photodynamic diagnosis and related optical techniques for the management of malignant glioma

R. Sroka, H. Stepp, W. Beyer, N. Markwardt, A. Rühm

Proceedings Volume 10340, International Conference on Biophotonics V; 1034014 (2017) https://doi.org/10.1117/12.2270006
Event: International Conference on Biophotonics V, 2017, Perth, Australia

Abstract

Malignant gliomas are a devastating brain tumor disease with very poor prognosis. Stereotactic biopsy sampling is routinely used in larger neurosurgical centers to confirm the diagnosis of a suspected brain tumor. This procedure is associated with risk of blood vessel rupture as well as false-negative results. Recent investigations suggest a potential of light-based techniques to improve both therapy and diagnosis of GBM. Optical guidance can be utilized to improve the biopsy sampling procedure in terms of safety, reliability, and efficacy. Recording of optical signals (transmission, remission, fluorescence) can be potentially integrated into a biopsy needle for providing optical detection of tumor tissue and blood vessel recognition during the biopsy sampling. Optical signals can also be used for monitoring purposes during photodynamic therapy. Here, fluorescence signals recorded before the treatment indicate the presence and accumulation level of photosensitizer, while photobleaching of the photosensitizer fluorescence during the treatment can be used as a measure of the effectiveness of the therapy. Finally, transmitted light can reveal problematic tissue-optical conditions as well as changes of the optical properties of the treated tissue, which may be relevant with regard to treatment prognosis and strategy. Different optical concepts for interstitial PDT monitoring and optical tissue property assessment are presented.

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R. Sroka, H. Stepp, W. Beyer, N. Markwardt, and A. Rühm "Photodynamic diagnosis and related optical techniques for the management of malignant glioma", Proc. SPIE 10340, International Conference on Biophotonics V, 1034014 (29 April 2017); https://doi.org/10.1117/12.2270006

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KEYWORDS

Tissue optics

Tumors

Luminescence

Tissues

Integrated optics

Phototherapy

Reliability

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