Spatial-impulse-response-dependent back-projection using the non-stationary convolution in optoacoustic mesoscopy

Tong Lu; Yihan Wang; Feng Gao; Huijuan Zhao; Vasilis Ntziachristos; Jiao Li

doi:10.1117/12.2290000

19 February 2018 Spatial-impulse-response-dependent back-projection using the non-stationary convolution in optoacoustic mesoscopy

Tong Lu, Yihan Wang, Feng Gao, Huijuan Zhao, Vasilis Ntziachristos, Jiao Li

Author Affiliations +

Proceedings Volume 10494, Photons Plus Ultrasound: Imaging and Sensing 2018; 104943R (2018) https://doi.org/10.1117/12.2290000
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

Photoacoustic mesoscopy (PAMe), offering high-resolution (sub-100-μm) and high optical contrast imaging at the depth of 1-10 mm, generally obtains massive collection data using a high-frequency focused ultrasonic transducer. The spatial impulse response (SIR) of this focused transducer causes the distortion of measured signals in both duration and amplitude. Thus, the reconstruction method considering the SIR needs to be investigated in the computation-economic way for PAMe. Here, we present a modified back-projection algorithm, by introducing a SIR-dependent calibration process using a non-satationary convolution method. The proposed method is performed on numerical simulations and phantom experiments of microspheres with diameter of both 50 μm and 100 μm, and the improvement of image fidelity of this method is proved to be evident by methodology parameters. The results demonstrate that, the images reconstructed when the SIR of transducer is accounted for have higher contrast-to-noise ratio and more reasonable spatial resolution, compared to the common back-projection algorithm.

Citation Download Citation

Tong Lu, Yihan Wang, Feng Gao, Huijuan Zhao, Vasilis Ntziachristos, and Jiao Li "Spatial-impulse-response-dependent back-projection using the non-stationary convolution in optoacoustic mesoscopy", Proc. SPIE 10494, Photons Plus Ultrasound: Imaging and Sensing 2018, 104943R (19 February 2018); https://doi.org/10.1117/12.2290000

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