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17 September 2018 Fluorescent Pt nanoclusters and their application to bio-imaging (Conference Presentation)
Hidekazu Ishitobi, Kyoko Masui, Yasushi Inouye
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Proceedings Volume 10722, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVI; 107220Y (2018) https://doi.org/10.1117/12.2320156
Event: SPIE Nanoscience + Engineering, 2018, San Diego, California, United States
Abstract
When the size of metallic nanoparticles becomes smaller than 1 nm, of which nanostructures are composed of several tens of atoms, the plasmonic effect disappears and the electronic energy levels of the nanoparticles called as nanoclusters are quantized. Then, the nanoclusters can emit fluorescence of which wavelength depends on their size. We investigated synthetic method of Platinum nanoclusters (Pt NCs) that exhibit blue to yellow photoluminescence by a facile one-pot reduction method. They were synthesized from the mixture of H2PtCl6, hyper-branched polyethylenimine (PEI), and L-ascorbic acid, resulting in the formation stabilized with the amino groups in the cavities formed by coiled PEI ligands. The chain conformation of cationic polymer PEI depends on pH of solution. By controlling pH of the synthesis solution, the size of Pt NCs@PEI changes and their fluorescent wavelength can be tuned. Pt NCs@PEI were applied to the labeling of Chemokine receptors of the membrane of cancer HeLa cells and Glutamate receptors of the membrane of neural cells by binding them to an antibody via a conjugate protein for bio-imaging. They showed lower cell cytotoxicity than other nanoparticles such as Q-dots@COOH, indicating that they have better cell viability and great potential for biological applications.
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Hidekazu Ishitobi, Kyoko Masui, and Yasushi Inouye "Fluorescent Pt nanoclusters and their application to bio-imaging (Conference Presentation)", Proc. SPIE 10722, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVI, 107220Y (17 September 2018); https://doi.org/10.1117/12.2320156
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KEYWORDS
Platinum
Nanoparticles
Luminescence
Receptors
Cancer
Chemical species
Nanostructures
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