Targeting drug-resistant glioblastoma stem cells using photodynamic therapy  (Conference Presentation)

Bryan Q. Spring; Kohei Watanabe; Megumi Ichikawa; Srivalleesha Mallidi; Tatsuyuki Matsudaira; Dmitriy Timerman; Hiroaki Wakimoto; Tayyaba Hasan

doi:10.1117/12.2510962

7 March 2019 Targeting drug-resistant glioblastoma stem cells using photodynamic therapy (Conference Presentation)

Bryan Q. Spring, Kohei Watanabe, Megumi Ichikawa, Srivalleesha Mallidi, Tatsuyuki Matsudaira, Dmitriy Timerman, Hiroaki Wakimoto, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII; 1086004 (2019) https://doi.org/10.1117/12.2510962
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Standard chemoradiation often enriches drug-resistant tumor cell populations that can lead to recurrent and treatment-refractory disease. Preclinical models of glioblastoma brain tumors, for instance, suggest that the cancer stem cell subpopulation becomes enriched and re-populates the tumor milieu following conventional therapies. Here, we show evidence that photodynamic therapy (PDT) is effective against several patient-derived glioblastoma stem cell cultures. Moreover, sub-lethal PDT results in re-sensitization of cancer stem cell phenotypes with induced drug-resistance to chemotherapy.

Conference Presentation

Citation Download Citation

Bryan Q. Spring, Kohei Watanabe, Megumi Ichikawa, Srivalleesha Mallidi, Tatsuyuki Matsudaira, Dmitriy Timerman, Hiroaki Wakimoto, and Tayyaba Hasan "Targeting drug-resistant glioblastoma stem cells using photodynamic therapy (Conference Presentation)", Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 1086004 (7 March 2019); https://doi.org/10.1117/12.2510962

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