The study of focused ultrasound effect to increase the penetration of light for photodynamic therapy of deeper tissue

Seung Hee Han; Won Seok Chang; Jae Hyuk Kim

doi:10.1117/12.2534937

1 October 2019 The study of focused ultrasound effect to increase the penetration of light for photodynamic therapy of deeper tissue

Seung Hee Han, Won Seok Chang, Jae Hyuk Kim

Author Affiliations +

Proceedings Volume 11079, Medical Laser Applications and Laser-Tissue Interactions IX; 110791X (2019) https://doi.org/10.1117/12.2534937
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

This study investigates that the light source can be transmitted deeper for photodynamic treatment of deep locations using the biological correlations of Focused Ultrasound and tissue. we used the phenomenon that Focused Ultrasound induced changes in tissue structure. Ultrasound interacts with tissue through both thermal and non-thermal mechanisms and generates a variety of biological effects. We measured 1. Monte Carlo Simulation to measurement of the relationship between the constitutional deformation of the tissue and the transmittance of the light source 2. Measurement of the effect of the scattering coefficient. 3. Measurement of biological tissue by constitution modification with biological characteristics of ultrasound. a chest tissue phantom was sampled, and a system was developed with FUS and Laser. In conclusion, we could detect the possibility that the light source could penetrate deeper into the region of the tissue after the FUS was irradiated.

Citation Download Citation

Seung Hee Han, Won Seok Chang, and Jae Hyuk Kim "The study of focused ultrasound effect to increase the penetration of light for photodynamic therapy of deeper tissue", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110791X (1 October 2019); https://doi.org/10.1117/12.2534937

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