OCT and fluorescence SLO for guided laser delivery and longitudinal imaging in a murine model of targeted retinal laser injury (Conference Presentation)

Joseph D. Malone; Edward M. Levine; Yuankai K. Tao

doi:10.1117/12.2550167

9 March 2020 OCT and fluorescence SLO for guided laser delivery and longitudinal imaging in a murine model of targeted retinal laser injury (Conference Presentation)

Joseph D. Malone, Edward M. Levine, Yuankai K. Tao

Author Affiliations +

Proceedings Volume 11218, Ophthalmic Technologies XXX; 112181E (2020) https://doi.org/10.1117/12.2550167
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Mice are commonly used to model human retinal disease because of similarities in ocular anatomy and function and availability of transgenic phenotypes. Recently, targeted delivery of photo-lesions has been demonstrated using fundus imaging and a combined optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) system; however, these systems precluded simultaneous multimodality imaging. Here, we present multimodality OCT+SLO imaging combined with a photocoagulation laser and custom software that allows for targeted delivery of focal retinal laser injury under real-time en face OCT guidance. Longitudinal imaging results show lesions with varying degrees of retinal damage during an injury titration study.

Conference Presentation

Citation Download Citation

Joseph D. Malone, Edward M. Levine, and Yuankai K. Tao "OCT and fluorescence SLO for guided laser delivery and longitudinal imaging in a murine model of targeted retinal laser injury (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181E (9 March 2020); https://doi.org/10.1117/12.2550167

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