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5 March 2021 Quantitative bioluminescence tomography-guided system for pre-clinical radiotherapy research
Xiangkun Xu, Zijian Deng, Hamid Dehghani, Iulian Iordachita, Michael Lim, John Wong, Ken Kang-Hsin Wang
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Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 116391T (2021) https://doi.org/10.1117/12.2583223
Event: SPIE BiOS, 2021, Online Only
Conference Poster
Abstract
While CBCT provides excellent guidance capability, it is less adept at localizing soft tissue targets growing in a low image contrast environment. To advance image-guided irradiation for soft tissue targets, we developed quantitative bioluminescence tomography(QBLT) for small animal radiation research platform(SARRP). We presented a comprehensive approach to systematically tackle the challenging of BLT for in vivo target delineation, quantify its uncertainties in localization, and demonstrate the practicality for radiation guidance. Our QBLT-guided system provides a unique opportunity for investigators to guide conformal irradiation for soft tissue targets. The accurate image-guidance is expected to increase rigorous and reproducibility of scientific discovery.
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Xiangkun Xu, Zijian Deng, Hamid Dehghani, Iulian Iordachita, Michael Lim, John Wong, and Ken Kang-Hsin Wang "Quantitative bioluminescence tomography-guided system for pre-clinical radiotherapy research", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 116391T (5 March 2021); https://doi.org/10.1117/12.2583223
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KEYWORDS
Bioluminescence
Pre-clinical research
Radiotherapy
Tissues
Tumors
Imaging systems
Target recognition
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