Influence of human epidermal thickness on penetration depth of detected photons in spatially-resolved diffuse reflectance spectroscopy: a numerical study

Victor Colas; Christian Daul; Gregoire Khairallah; Marine Amouroux; Walter Blondel

doi:10.1117/12.2578203

5 March 2021 Influence of human epidermal thickness on penetration depth of detected photons in spatially-resolved diffuse reflectance spectroscopy: a numerical study

Victor Colas, Christian Daul, Gregoire Khairallah, Marine Amouroux, Walter Blondel

Author Affiliations +

Proceedings Volume 11640, Optical Interactions with Tissue and Cells XXXII; 116400H (2021) https://doi.org/10.1117/12.2578203
Event: SPIE BiOS, 2021, Online Only

Abstract

In the context of cutaneous carcinoma in vivo diagnosis, Diffuse Relectance (DR) acquired using Spatially Resolved (SR) optical biopsy, can be analysed to discard healthy from pathological areas. Indeed, carcinogenesis induces local morphological and metabolic changes affecting the skin optical answer to white light excitation. The present contribution aims at studying the epidermis thickness impact on the path and propagation depth distribution of DR photons in skin in the perspective of analyzing how these photons contribute to the corresponding acquired spectra carrying local physiological information from the visited layers. Modified CudaMCML-based simulations were performed on a five-layer human skin optical model using (i) wavelength-resolved scattering and absorption properties and (ii) the geometrical configuration of a multi-optical fiber probe implemented on a SR-DR spectroscopic device currently used in clinics. Through maps of scattering events and histograms of maximum probed depth, we provide numerical evidences linking the characteristic penetration depth of the detected photons to their wavelengths and four source-sensor distances for thin, intermediate and wide skin thicknesses model. The study provides qualitative and quantitative tools that can be useful during the design of an optical SR-DR spectroscopy biopsy device.

Conference Presentation

Citation Download Citation

Victor Colas, Christian Daul, Gregoire Khairallah, Marine Amouroux, and Walter Blondel "Influence of human epidermal thickness on penetration depth of detected photons in spatially-resolved diffuse reflectance spectroscopy: a numerical study", Proc. SPIE 11640, Optical Interactions with Tissue and Cells XXXII, 116400H (5 March 2021); https://doi.org/10.1117/12.2578203

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available