Acoustic resolution photoacoustic doppler flowmetry for assessment of  patient rectal cancer blood perfusion

Sitai Kou; Xiandong Leng; Hongbo Luo; William C. Chapman Jr.; Matthew Mutch; Quing Zhu

doi:10.1117/12.2578882

6 March 2021 Acoustic resolution photoacoustic doppler flowmetry for assessment of patient rectal cancer blood perfusion

Sitai Kou, Xiandong Leng, Hongbo Luo, William C. Chapman Jr., Matthew Mutch, Quing Zhu

Author Affiliations +

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116420U (2021) https://doi.org/10.1117/12.2578882
Event: SPIE BiOS, 2021, Online Only

Abstract

Currently, post-therapy evaluation of colorectal cancer relies on functional MRI, which does not possess resolution and sensitivity well-suited for the task. Endorectal photoacoustic microscopy offers blood contrast and much higher resolution in imaging residual tumor vasculature. Correlational acoustic resolution photoacoustic doppler flowmetry with amplitude dependent masking was implemented, validated with simulations and phantom experiments, and put into use on colorectal patient scanning data. Doppler velocity map demonstrated potential in highlighting flow in the photoacoustic signal region while removing stationary absorber signals, showing vascular density and distribution in agreement with current understanding of colorectal cancer pathology.

Conference Presentation

Citation Download Citation

Sitai Kou, Xiandong Leng, Hongbo Luo, William C. Chapman Jr., Matthew Mutch, and Quing Zhu "Acoustic resolution photoacoustic doppler flowmetry for assessment of patient rectal cancer blood perfusion", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116420U (6 March 2021); https://doi.org/10.1117/12.2578882

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