Activated platelet detection using a glycoprotein IIb/IIIa targeted near infrared fluorescence imaging probe

Khanh Ha; Farouc A. Jaffer; Jason R. McCarthy; Xiaoxin Zheng; Chase Kessinger

doi:10.1117/12.2577254

8 March 2021 Activated platelet detection using a glycoprotein IIb/IIIa targeted near infrared fluorescence imaging probe

Khanh Ha, Farouc A. Jaffer, Jason R. McCarthy, Xiaoxin Zheng, Chase Kessinger

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Proceedings Volume 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII; 1166005 (2021) https://doi.org/10.1117/12.2577254
Event: SPIE BiOS, 2021, Online Only

Abstract

Activated platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis, as well as in atherosclerosis and cancer. More recent studies demonstrate further an important role for platelets in generating a permissive microenvironment for tumor growth, and the promotion of invasion and metastasis. To advance the in vivo study of the biological activity of this activated cell type from basic experimental to a clinical focus, new translatable platelet-specific molecular imaging agents are required. Herein, we report the development of a near-infrared fluorescence probe based upon tirofiban, a clinically-approved small molecule glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa). Through in vitro experiments with human platelets, and in vivo in a murine model of deep vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, thereby enabling rapid in vivo visualization within the vasculature

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Khanh Ha, Farouc A. Jaffer, Jason R. McCarthy, Xiaoxin Zheng, and Chase Kessinger "Activated platelet detection using a glycoprotein IIb/IIIa targeted near infrared fluorescence imaging probe", Proc. SPIE 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII, 1166005 (8 March 2021); https://doi.org/10.1117/12.2577254

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KEYWORDS

Near infrared

Luminescence

Target detection

Biological detection systems

In vivo imaging

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