From blur to optical oasis: image resolution improvements to speciate parasitic infections

John J. Tomes; Simon Astley; Line Macaire; Claire Reigate; Rachel Cross

doi:10.1117/12.2601534

6 October 2021 From blur to optical oasis: image resolution improvements to speciate parasitic infections

John J. Tomes, Simon Astley, Line Macaire, Claire Reigate, Rachel Cross

Proceedings Volume 11879, Frontiers in Biophotonics and Imaging; 1187904 (2021) https://doi.org/10.1117/12.2601534
Event: SPIE Photonex, 2021, Glasgow, United Kingdom

Abstract

Here we describe the evaluation and subsequent re-design of an optical, point of care parasite infection diagnostic instrument. The original optical system was resolution limited by the focusing objective which had an f5.6 numerical aperture with an effective 3Mega pixel performance giving a minimum resolution of 3.73μm. Changing the objective to an f2.4 lens and employing 12Mega pixel sensor, combined with illumination modelling and re-design, improved resolution to 1.46μm within the necessary 3mm field of view. This presents a simple case for change which leads to benefits in both instrument sensitivity and improved parasite identification and speciation.

Conference Presentation

Citation Download Citation

John J. Tomes, Simon Astley, Line Macaire, Claire Reigate, and Rachel Cross "From blur to optical oasis: image resolution improvements to speciate parasitic infections", Proc. SPIE 11879, Frontiers in Biophotonics and Imaging, 1187904 (6 October 2021); https://doi.org/10.1117/12.2601534

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