Light-assisted drying (LAD) for anhydrous preservation of biologics: processing sample volumes comparable to a therapeutic dose

Daniel Furr; Anteneh Tsegaye; Madeline Kern; Gunnar Olson; Susan Trammell

doi:10.1117/12.2609907

2 March 2022 Light-assisted drying (LAD) for anhydrous preservation of biologics: processing sample volumes comparable to a therapeutic dose

Daniel Furr, Anteneh Tsegaye, Madeline Kern, Gunnar Olson, Susan Trammell

Author Affiliations +

Proceedings Volume 11950, Optics and Biophotonics in Low-Resource Settings VIII; 1195005 (2022) https://doi.org/10.1117/12.2609907
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Cold-chain storage can be challenging and expensive for the transportation and storage of biologics, especially in low-resource settings. Recent research has demonstrated that anhydrous preservation in a trehalose amorphous solid matrix offers an alternative to freeze drying for the preservation of biologics. We have previously described a new processing technique, light assisted drying (LAD), to create trehalose preservation matrices of small volume (40 μL) samples. LAD uses illumination by near-infrared laser light to selectively heat water and speed dehydration. In this study we apply the LAD technique to large volume samples (250 μL) that are more comparable to therapeutic doses.

Conference Presentation

Citation Download Citation

Daniel Furr, Anteneh Tsegaye, Madeline Kern, Gunnar Olson, and Susan Trammell "Light-assisted drying (LAD) for anhydrous preservation of biologics: processing sample volumes comparable to a therapeutic dose", Proc. SPIE 11950, Optics and Biophotonics in Low-Resource Settings VIII, 1195005 (2 March 2022); https://doi.org/10.1117/12.2609907

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