Improving colorectal cancer detection by extending the near-infrared wavelength range and tissue probed depth of diffuse reflectance spectroscopy: a support vector machine approach

Marcelo Saito Nogueira; Siddra Maryam; Michael Amissah; Huihui Lu; Noel Lynch; Shane Killeen; Micheal O'Riordain; Stefan Andersson-Engels

doi:10.1117/12.2610497

2 March 2022 Improving colorectal cancer detection by extending the near-infrared wavelength range and tissue probed depth of diffuse reflectance spectroscopy: a support vector machine approach

Marcelo Saito Nogueira, Siddra Maryam, Michael Amissah, Huihui Lu, Noel Lynch, Shane Killeen, Micheal O'Riordain, Stefan Andersson-Engels

Author Affiliations +

Proceedings Volume 11954, Optical Biopsy XX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 1195404 (2022) https://doi.org/10.1117/12.2610497
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Colorectal cancer (CRC) is the second most deadly and third most common type of cancer worldwide. In this study, we assessed the improvement of the diagnostic potential of diffuse reflectance spectroscopy (DRS) for CRC detection upon extending the tissue probed depth (up to 2mm) and wavelength ranges (350-1919 nm) investigated in previous studies. We analyzed almost 3000 DR spectra (7.5 times more than previous studies) collected with 630-µm and 2500-µm source-detector distance probes by using support vector machines with potential to automate tissue classification. We achieved 96.1% sensitivity and 95.7% specificity and 0.987±0.005 AUC on tissue classification.

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Marcelo Saito Nogueira, Siddra Maryam, Michael Amissah, Huihui Lu, Noel Lynch, Shane Killeen, Micheal O'Riordain, and Stefan Andersson-Engels "Improving colorectal cancer detection by extending the near-infrared wavelength range and tissue probed depth of diffuse reflectance spectroscopy: a support vector machine approach", Proc. SPIE 11954, Optical Biopsy XX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1195404 (2 March 2022); https://doi.org/10.1117/12.2610497

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