Novel benzophenothiazinium photosensitizers: preliminary in-vivo results

Anthony H. Cincotta; Louis Cincotta; James W. Foley

doi:10.1117/12.17666

1 July 1990 Novel benzophenothiazinium photosensitizers: preliminary in-vivo results

Anthony H. Cincotta, Louis Cincotta, James W. Foley

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17666
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

The photochemotherapeutic properties of several novel benzophenothiazines were evaluated zn-vzvo in three distinct tumor types consisting of a murine sarcoma, human carcinoma, and a rat glioma. Subcutaneous or intravenous administration of dyes to tumor bearing animals coupled with irradiation of the tumor area with 640 nm light resulted in substantial tumor necrosis 24h post photodynamic therapy as determined by histological evaluation. Significantly, there was minimal concurrent damage to the surrounding normal tissue. These results offer further evidence for the potential usefulness of benzophenothiazines in the photodynamic therapy of neoplasms.

Citation Download Citation

Anthony H. Cincotta, Louis Cincotta, and James W. Foley "Novel benzophenothiazinium photosensitizers: preliminary in-vivo results", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17666

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