Polarization-based skin cancer detection in vivo

Lioudmila Tchvialeva; Daniel C. Louie; Yuheng Wang; Sunil Kalia; Harvey Lui; Tim K. Lee

doi:10.1117/12.2621081

20 December 2021 Polarization-based skin cancer detection in vivo

Lioudmila Tchvialeva, Daniel C. Louie, Yuheng Wang, Sunil Kalia, Harvey Lui, Tim K. Lee

Proceedings Volume 12126, Fifteenth International Conference on Correlation Optics; 121262P (2021) https://doi.org/10.1117/12.2621081
Event: Fifteenth International Conference on Correlation Optics, 2021, Chernivtsi, Ukraine

Abstract

Recently optical imaging is focused on non-invasive methods which could be automated and provide diagnostics in vivo. Coherence and polarization encoding the wave phase transformation create additional channels of information compared with the amplitude-based techniques. The modification of polarization properties like depolarization, birefringence, and diattenuation are the subject of polarimetry. One of the depolarization metrics is the Degree of Polarization (DOP), which represent the fraction of polarized light maintained while light propagates in media, ranging from 1 for fully polarized to 0 for totally depolarized light. After constructing a one-shot Stokes polarimetry probe, we conducted a preliminary clinical trial including 20 benign, 28 malignant skin lesions. Also 59 normal skin sites where tested. Using DOP as a diagnostics criterion we were able to separate Malignant Melanomas against all other lesions. Another depolarization metric tested was the Polarization Memory Rate (PMR) which characterizes the decay of circularly polarized light relative to linearly polarized light as light propagates in a medium. PMR demonstrates a strong diagnostics potential separating all cancer against benign lesions.

Citation Download Citation

Lioudmila Tchvialeva, Daniel C. Louie, Yuheng Wang, Sunil Kalia, Harvey Lui, and Tim K. Lee "Polarization-based skin cancer detection in vivo", Proc. SPIE 12126, Fifteenth International Conference on Correlation Optics, 121262P (20 December 2021); https://doi.org/10.1117/12.2621081

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
7 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Polarization

Skin

Cancer

Skin cancer

Polarimetry

Diagnostics

In vivo imaging

Show All Keywords

Keywords/Phrases

Search In:

Publication Years