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3 October 2022 Longitudinal xenograft zebrafish investigation using polarization-sensitive Jones-matrix optical coherence tomography (Conference Presentation)
Antonia Lichtenegger, Junya Tamaoki, Tomoko Mori, Pradipta Mukherjee, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Satoshi Matsusaka, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno
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Proceedings Volume 12223, Interferometry XXI; 122230F (2022) https://doi.org/10.1117/12.2632878
Event: SPIE Optical Engineering + Applications, 2022, San Diego, California, United States
Abstract
The zebrafish is a valuable animal model in pre-clinical cancer research. Optical coherence tomography (OCT) is a non-invasive optical imaging technique, which provides a label-free and three-dimensional method to investigate the tissue structure. Jones-matrix OCT (JM-OCT) is a functional extension of conventional OCT, to gain additional tissue specific contrast by analyzing the polarization states of the back-scattered light. In this work we present the longitudinal investigation of in vivo wildtype and a tumor xenograft zebrafish model using our JM-OCT prototype. The scattering and depth-resolved polarization properties in control versus tumor regions were analyzed and compared to results obtained from histology.
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Antonia Lichtenegger, Junya Tamaoki, Tomoko Mori, Pradipta Mukherjee, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Satoshi Matsusaka, Makoto Kobayashi, Bernhard Baumann, and Yoshiaki Yasuno "Longitudinal xenograft zebrafish investigation using polarization-sensitive Jones-matrix optical coherence tomography (Conference Presentation)", Proc. SPIE 12223, Interferometry XXI, 122230F (3 October 2022); https://doi.org/10.1117/12.2632878
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KEYWORDS
Optical coherence tomography
Polarization
Breast cancer
Cancer
Genetics
Prototyping
Scattering
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