Prof. Makoto Kobayashi Profile

Prof. Makoto Kobayashi

at Univ of Tsukuba

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Author

Publications (9)

Proceedings Article | 27 March 2023 Poster

Disperse scatterer model of OCT and its application to design volumetric differential contrast imaging

Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtenegger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tmoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123671Q (2023) https://doi.org/10.1117/12.2652325

KEYWORDS: Optical coherence tomography, Refractive index, Digital image correlation, Signal processing, Coherence imaging, 3D modeling, Statistical modeling, Optical imaging, Microscopy, Laser beam diagnostics

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Proceedings Article | 16 March 2023 Presentation

Volumetric differential contrast imaging by computationally augmented optical coherence tomography microscopy (Conference Presentation)

Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtengger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tomoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12391, PC1239111 (2023) https://doi.org/10.1117/12.2648746

KEYWORDS: Optical coherence tomography, Microscopy, Optical microscopy, Refractive index, Digital image correlation, 3D modeling, Signal processing, Tumors, Optical imaging, Laser beam diagnostics

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Proceedings Article | 16 March 2023 Presentation

Non-invasive and label-free zebrafish investigations using polarization-sensitive optical coherence tomography (Conference Presentation)

Antonia Lichtenegger, Junya Tamaoki, Pradipta Mukherjee, Roxane Licandro, Lida Zhu, Tomoko Mori, Rion Morishita, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Satoshi Matsusaka, Martin Distel, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume PC12391, PC123910Z (2023) https://doi.org/10.1117/12.2646760

KEYWORDS: Optical coherence tomography, Tumors, Prototyping, Polarization, 3D modeling, 3D image processing, Tumor growth modeling, Image resolution, Visualization, Tissues

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Proceedings Article | 8 March 2023 Presentation + Paper

Multiple scattering suppression by multi-focus averaging in Jones-matrix optical coherence tomography

Lida Zhu, Shuichi Makita, Yiheng Lim, Junya Tamaoki, Yiqiang Zhu, Makoto Kobayashi, Yoshiaki Yasuno

Proceedings Volume 12367, 123670E (2023) https://doi.org/10.1117/12.2652183

KEYWORDS: Optical coherence tomography, Scattering, Biological samples, Polarization, Multiple scattering, Modulation, Tissues

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Optical coherence tomography (OCT) has been utilized to investigate the optical properties of tissue in animal model studies. Polarization sensitive OCT (PS-OCT) is one of the functional extensions of OCT, which provides additional contrasts such as birefringence and degree-of-polarization uniformity (DOPU). It enables multi-contrast imaging for discrimination of tissue properties in biological samples. However, biological samples often exhibit multiple scattering (MS). It severely hampers the penetration depth and degrades the optical property measurement in deep regions for both OCT and PS-OCT. In a recently presented work, it was found that all of the scattering OCT value, birefringence value, and DOPU value were altered if they were measured at the deep region. This alteration is suspected to be artifacts caused by MS. So far, various methods have been proposed to tackle the MS issue. One is averaging several images with decorrelated MS signals. The decorrelation of MS signals was realized by wavefront shaping with complex devices such as spatial light modulators or deformable mirrors. However, these optics increase the cost and system complexity, and the wavefront shaping is still challenging. Simple hardware, such as multimode fiber, was only demonstrated in full-field OCT. In this work, we present a method termed as “multi-focus averaging” (MFA) to suppress the MS effect and improve the image contrast in deep regions of scattering samples. It uses focus modulation by a tunable lens to decorrelate MS signals among multiple acquisitions, and computational refocusing is used to cancel the different defocus during focus modulation. The refocused OCT signals are averaged in complex to reduce MS signals. It is demonstrated in standard OCT scheme, and a scattering phantom and a post-mortem zebrafish are used to validate the intensity contrast improvement. Results show that MFA images can provide better intensity contrast than standard complex averaging in scattering samples. In addition, we further adapt this method to PS-OCT to suppress the MS and to improve the accuracy of polarization sensitive measurement. We found MFA mitigated low-DOPU artifact in polarization sensitive measurement.

Proceedings Article | 3 October 2022 Presentation

Longitudinal xenograft zebrafish investigation using polarization-sensitive Jones-matrix optical coherence tomography (Conference Presentation)

Antonia Lichtenegger, Junya Tamaoki, Tomoko Mori, Pradipta Mukherjee, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Satoshi Matsusaka, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume 12223, 122230F (2022) https://doi.org/10.1117/12.2632878

KEYWORDS: Optical coherence tomography, Polarization, Tumors, Tumor growth modeling, Tissue optics, Scattering, Prototyping, Genetics, Cancer, Breast cancer

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Proceedings Article | 7 March 2022 Poster + Presentation + Paper

Multi-focus average for multiple scattering noise suppression in optical coherence tomography

Lida Zhu, Shuichi Makita, Antonia Litchtenegger, Junya Tamaoki, Kensuke Oikawa, Pradipta Mukherjee, Yiheng Lim, Makoto Kobayashi, Jiajie Luo, Yoshiaki Yasuno

Proceedings Volume 11948, 119480M (2022) https://doi.org/10.1117/12.2609190

KEYWORDS: Optical coherence tomography, Scattering, Multiple scattering, Tissues, Light scattering

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Proceedings Article | 2 March 2022 Presentation

Volumetric differential-phase imaging in scattering mode by optical coherence tomography

Kiriko Tomita, Daisuke Oida, Antonia Lichtenegger, Makoto Kobayashi, Junya Tamaoki, Lixuan Bian, Shuichi Makita, Kensuke Oikawa, Rion Morishita, Yoshiaki Yasuno

Proceedings Volume PC11972, PC119720O (2022) https://doi.org/10.1117/12.2608606

KEYWORDS: Optical coherence tomography, Light scattering, Scattering, Refractive index, Phase measurement, Tissue optics, Digital image correlation, Tissues, Phase contrast, Optical properties

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Proceedings Article | 2 March 2022 Presentation

Non-invasive, structural and functional imaging of in vivo zebrafish in various development stages using Jones matrix optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Junya Tamaoki, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume PC11972, PC119720P (2022) https://doi.org/10.1117/12.2606979

KEYWORDS: Optical coherence tomography, In vivo imaging, Polarization, Functional imaging, Visualization, Prototyping, Eye, Birefringence, 3D image processing, Tumor growth modeling

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SPIE Journal Paper | 21 January 2022 Open Access

Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Junya Tamaoki, Lixuan Bian, Lida Zhu, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

JBO, Vol. 27, Issue 01, 016001, (January 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.1.016001

KEYWORDS: Birefringence, Optical coherence tomography, In vivo imaging, Scattering, Polarization, Signal attenuation, Prototyping, Eye, Spinal cord, Skin

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