Rigid endomicroscopic system for multiphoton imaging and tissue ablation in the head and neck region

Chenting Lai; Bernhard Messerschmidt; Karl Reichwald; Sven Flämig; Tino Eidam; Fabian Stutzki; Matteo Calvarese; Hyeonsoo Bae; Tobias Meyer-Zedler; Michael Schmitt; Herbert Gross; Franziska Hoffmann; Orlando Guntinas-Lichius; Juergen Popp

doi:10.1117/12.2650081

14 March 2023 Rigid endomicroscopic system for multiphoton imaging and tissue ablation in the head and neck region

Chenting Lai, Bernhard Messerschmidt, Karl Reichwald, Sven Flämig, Tino Eidam, Fabian Stutzki, Matteo Calvarese, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Herbert Gross, Franziska Hoffmann, Orlando Guntinas-Lichius, Juergen Popp

Author Affiliations +

Proceedings Volume 12356, Endoscopic Microscopy XVIII; 1235609 (2023) https://doi.org/10.1117/12.2650081
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Here, we present a new handheld multiphoton endomicroscopic system for tumor diagnosis in the head and neck region. It consists of an approx. 25 cm long rigid endomicroscopic probe with two variants (0° and 45° bended tip), connected to a handheld scan-head. The system can achieve a field of view > 600 μm for coherent anti-Stokes Raman scattering (CARS) and other nonlinear imaging techniques by a non-descanned detection channel, and laser confocal imaging with indocyanine green (ICG) by a descanned detection channel. Furthermore, high-power femtosecond laser pulses can be transmitted through the system for precise tissue ablation without the risk of damaging the optical components.

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Citation Download Citation

Chenting Lai, Bernhard Messerschmidt, Karl Reichwald, Sven Flämig, Tino Eidam, Fabian Stutzki, Matteo Calvarese, Hyeonsoo Bae, Tobias Meyer-Zedler, Michael Schmitt, Herbert Gross, Franziska Hoffmann, Orlando Guntinas-Lichius, and Juergen Popp "Rigid endomicroscopic system for multiphoton imaging and tissue ablation in the head and neck region", Proc. SPIE 12356, Endoscopic Microscopy XVIII, 1235609 (14 March 2023); https://doi.org/10.1117/12.2650081

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