Interstitial laser and chemotherapy combined for treatment of human squamous cell carcinoma

Romaine E. Saxton; Ines P. Graeber; Michael J. Suh; Woo H. Paek; Marcos B. Paiva; Dan J. Castro

doi:10.1117/12.275040

22 May 1997 Interstitial laser and chemotherapy combined for treatment of human squamous cell carcinoma

Romaine E. Saxton, Ines P. Graeber, Michael J. Suh, Woo H. Paek, Marcos B. Paiva, Dan J. Castro

Proceedings Volume 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII; (1997) https://doi.org/10.1117/12.275040
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

We have tested a combined treatment for squamous cell carcinoma based on laser activation of anti-cancer drugs in human solid tumors. Cisplatinum and the new anthrapyrazole CI- 941 are reported to interact with photothermal energy. Combined intratumor drug and interstitial laser therapy were tested in nude mice bearing human squamous cell carcinomas grown as subcutaneous tumors. Cisplatinum injection (1.2 mg/500 mg tumor) 4 hours before KTP laser fiberoptic treatment (532 nm, 0.8 W, 10 sec/site, 300 J) resulted in complete tumor regression in 6/8 animals, while intratumor drug alone led to partial regression and tumor regrowth in 10/10 mice during 12 weeks followup. Laser treatment alone resulted in ablation followed by recurrence in 7/8 cases. Similar laser treatment 4 hours after injection of the light sensitive anthrapyrazole CI-941 led to complete tumor regression in 15/22 cases. CI-941 alone at drug levels up to 1.2 mg/gm tumor in 30 mice induced stasis followed by progression in all cases. Finally, tumor retention of ¹⁴C-CI-941 in mice 4 hrs after intralesional injection was 200-fold higher than via the systemic route and by 24 hrs remained 40-fold higher, but drug levels in normal tissues were reduced 10 - 100 fold. The data suggest laser chemotherapy may be a useful new treatment for human cancer.

Citation Download Citation

Romaine E. Saxton, Ines P. Graeber, Michael J. Suh, Woo H. Paek, Marcos B. Paiva, and Dan J. Castro "Interstitial laser and chemotherapy combined for treatment of human squamous cell carcinoma", Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); https://doi.org/10.1117/12.275040

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KEYWORDS

Tumors

Laser therapeutics

Fiber optics

Cancer

Tissues

Laser ablation

Head

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