The role of fluid shear stress in regulating photoimmunotherapy efficacy and immunogenic cell death (Conference Presentation)

Aaron Sorrin; Keri Zhou; Katherine May; Cindy Liu; Barry J. Liang; Dana M. Roque; Huang Chiao Huang

doi:10.1117/12.2654653

14 March 2023 The role of fluid shear stress in regulating photoimmunotherapy efficacy and immunogenic cell death (Conference Presentation)

Aaron Sorrin, Keri Zhou, Katherine May, Cindy Liu, Barry J. Liang, Dana M. Roque, Huang Chiao Huang

Author Affiliations +

Proceedings Volume 12380, Biophotonics and Immune Responses XVIII; 1238008 (2023) https://doi.org/10.1117/12.2654653
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Photoimmunotherapy employs antibody-photosensitizer constructs (photoimmunoconjugates) for targeted cancer ablation through the generation of reactive oxygen species. While this approach enhances cancer cell specificity, it sacrifices cellular uptake. This study addresses this limitation through two strategies with an emphasis on anti-cancer immunogenicity: 1) utilizing fluid shear stress to mediate delivery, and 2) leveraging nanoengineering approaches to maximize photoimmunoconjugate payload. Results reveal that fluid shear stress promotes photosensitizer delivery and anti-tumor immune response while modulating subcellular localization. By shedding light on improved delivery strategies and formulations, this study generates important implications for the clinical implementation of photoimmunotherapy.

Conference Presentation

Citation Download Citation

Aaron Sorrin, Keri Zhou, Katherine May, Cindy Liu, Barry J. Liang, Dana M. Roque, and Huang Chiao Huang "The role of fluid shear stress in regulating photoimmunotherapy efficacy and immunogenic cell death (Conference Presentation)", Proc. SPIE 12380, Biophotonics and Immune Responses XVIII, 1238008 (14 March 2023); https://doi.org/10.1117/12.2654653

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