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11 August 2023 Friction in quantitative micro-elastography
Kai L. Metzner, Qi Fang, Rowan W. Sanderson, Alireza Mowla, Brendan F. Kennedy
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Proceedings Volume 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V; 1263214 (2023) https://doi.org/10.1117/12.2669463
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany
Abstract
Quantitative Micro-Elastography (QME), an emerging compression optical coherence elastography technique, is used to measure the mechanical properties of tissue on the microscale. As QME requires contact between the loading plate and the sample, knowledge of the boundary conditions at the contact surface, including friction, is required to accurately calculate elasticity. In previous implementations of QME, a lubricant is applied at the contact surfaces, and it is assumed that this results in negligible friction. In this work, for the first time, we demonstrate that experimental factors including the application method and viscosity of the lubricant, as well as the mechanical contrast between the compliant layer and the sample affect friction and, therefore, the accuracy of QME. For instance, in the absence of appropriate lubrication, errors as large as 92% were observed, while the development of an optimized lubrication protocol provided accurate elasticity measurements for a wide range of samples elasticity (from 3 kPa to 130 kPa) to within 10% error.
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Kai L. Metzner, Qi Fang, Rowan W. Sanderson, Alireza Mowla, and Brendan F. Kennedy "Friction in quantitative micro-elastography", Proc. SPIE 12632, Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 1263214 (11 August 2023); https://doi.org/10.1117/12.2669463
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KEYWORDS
Elasticity
Biological samples
Viscosity
Tissues
Biological imaging
Elastography
Optical coherence tomography
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