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27 November 2023 Elastic wave imaging for elasticity measurements using handheld optical coherence elastography
Shuo Liu, Jiang Zhu, Chongyang Wang, Xiaochen Meng, Fan Fan
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Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127701T (2023) https://doi.org/10.1117/12.2686447
Event: SPIE/COS Photonics Asia, 2023, Beijing, China
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Abstract
Optical coherence tomography (OCT) enables high-resolution, label-free two-dimensional cross-sectional and three-dimensional volumetric imaging of biological tissues. Combining OCT imaging with external force excitation, optical coherence elastography (OCE) provides noninvasive elasticity quantification of samples for the pathological analysis of tissues and early diagnosis of diseases. However, the OCE system with a fixed OCT sample arm cannot be used for elasticity measurements of tissues located in a narrow space, such as an oral cavity and an ear canal, because the OCT beam and external force cannot easily reach the tissues. In this study, we developed a handheld OCE method for the elasticity measurements based on elastic wave imaging. The handheld probe integrated an air pulse excitation unit and a microelectromechanical system-based scan imaging unit. A short air pulse induced the elastic wave in a sample. Then the OCT data was captured by an M-B scan protocol, and the tissue vibration was analyzed by Doppler phase shifts. After elastic wave visualization, the elastic wave velocity was calculated for the elasticity quantification of the sample. The results show that the handheld OCE method can induce and image the elastic wave and, thus, quantify the elastic modulus with high flexibility for the tissue in a narrow, deep space.
(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Shuo Liu, Jiang Zhu, Chongyang Wang, Xiaochen Meng, and Fan Fan "Elastic wave imaging for elasticity measurements using handheld optical coherence elastography", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127701T (27 November 2023); https://doi.org/10.1117/12.2686447
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KEYWORDS
Elasticity
Optical coherence tomography
Biological imaging
Elastography
Imaging systems
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