Unclad optical fiber tips for plasmonic biosensing of heart failure biomarker

Ana Sofia Assunção; Miguel Vidal; Médéric Loyez; Christophe Caucheteur; Florinda M. Costa; José Mesquita-Bastos; Sónia O. Pereira; Cátia Leitão

doi:10.1117/12.2678368

23 May 2023 Unclad optical fiber tips for plasmonic biosensing of heart failure biomarker

Ana Sofia Assunção, Miguel Vidal, Médéric Loyez, Christophe Caucheteur, Florinda M. Costa, José Mesquita-Bastos, Sónia O. Pereira, Cátia Leitão

Author Affiliations +

Proceedings Volume 12643, European Workshop on Optical Fibre Sensors (EWOFS 2023); 1264319 (2023) https://doi.org/10.1117/12.2678368
Event: European Workshop on Optical Fibre Sensors (EWOFS 2023), 2023, Mons, Belgium

Abstract

Plasmonic optical fiber sensors have been investigated for biosensing purposes as they provide miniaturized devices with fast, label-free and highly sensitive responses. This study explores gold-coated optical fiber tip sensors, based on multimode fibers of 200 and 600 μm core diameters, for the detection of the heart failure biomarker N-terminal pro-Brain natriuretic peptide (NT-proBNP). The obtained results demonstrated that the 200 μm core tip reached the highest refractometric sensitivity, between 1158.54 and 2750.34 nm/RIU, and that both sensors responded to NT-proBNP concentrations in a range that included the values of clinical interest for the diagnosis of this cardiovascular disease, which correspond to 0.125 ng/mL and 0.300 ng/mL.

Citation Download Citation

Ana Sofia Assunção, Miguel Vidal, Médéric Loyez, Christophe Caucheteur, Florinda M. Costa, José Mesquita-Bastos, Sónia O. Pereira, and Cátia Leitão "Unclad optical fiber tips for plasmonic biosensing of heart failure biomarker", Proc. SPIE 12643, European Workshop on Optical Fibre Sensors (EWOFS 2023), 1264319 (23 May 2023); https://doi.org/10.1117/12.2678368

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