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20 June 2024 Waveguide scattering microscopy towards antibody biosensing
Jéssica E. S. Fonsaca, Wanderson S. R. Teixeira, Mohd Rehan, Bianca Tieppo, Daniella L. Vale, Lúcia A. M. Saito, Daniel Grasseschi, Christiano J. S. de Matos
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Proceedings Volume 12999, Optical Sensing and Detection VIII; 1299913 (2024) https://doi.org/10.1117/12.3022276
Event: SPIE Photonics Europe, 2024, Strasbourg, France
Abstract
Bovine brucellosis is an infectious illness caused mainly by Brucella abortus that may affect domestic and wild animals. Accurate and fast diagnosis is critical for disease control and eradication. Thus, we have identified Brucella abortus antibodies in bovine serum by exploring the agglutination process that is carried out when positive samples are mixed with the antigen. In this case, when placed above the on-chip integrated waveguide, the reaction led to scattering spots that indicated the positive serum. The monitoring was performed through optical images over time and analyzed by artificial neural network. Classification models were able to differentiate the positive from the negative samples with 81.25% accuracy. This work may represent a breakthrough for the diagnosis of other infectious diseases.
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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Jéssica E. S. Fonsaca, Wanderson S. R. Teixeira, Mohd Rehan, Bianca Tieppo, Daniella L. Vale, Lúcia A. M. Saito, Daniel Grasseschi, and Christiano J. S. de Matos "Waveguide scattering microscopy towards antibody biosensing", Proc. SPIE 12999, Optical Sensing and Detection VIII, 1299913 (20 June 2024); https://doi.org/10.1117/12.3022276
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KEYWORDS
Waveguides
Antibodies
Scattering
Biosensing
Microscopy
Animals
Data modeling
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