Detection of general anesthetics using a fluorescence-based sensor: incorporation of a single-fiber approach

Susan B. Abrams; Hillary L. MacDonald; Paul Yager

doi:10.1117/12.43860

1 July 1991 Detection of general anesthetics using a fluorescence-based sensor: incorporation of a single-fiber approach

Susan B. Abrams, Hillary L. MacDonald, Paul Yager

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Proceedings Volume 1420, Optical Fibers in Medicine VI; (1991) https://doi.org/10.1117/12.43860
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

A fiber-optic sensor for general anesthetics based on the phase transition of phospholipid vesicles has been developed and reported previously. The instrumentation and optics have been designed using two fibers and constructed in a portable configuration to allow multi-site testing. Because the phase transition is highly dependent on the surrounding temperature, it is necessary to obtain a temperature reference signal; use of a single-fiber configuration for both sample and reference permits the addition of a temperature transducer in the optrode without increasing its size. Because of the extreme turbidity of the liposomes, current theory does not predict whether a two-fiber or one-fiber approach will provide superior signal strength. The signal efficiency of the original dual-fiber configuration has been compared to that of a second dual-fiber configuration and a single-fiber system incorporating a fiber-optic coupler. Despite the reduced excitation power reaching the optrode, the single-fiber configuration produces a superior signal intensity. The addition of a custom-made Y-shaped fiber coupler enables switching from a dual-fiber design to the single-fiber optrode design without sacrificing portability.

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Susan B. Abrams, Hillary L. MacDonald, and Paul Yager "Detection of general anesthetics using a fluorescence-based sensor: incorporation of a single-fiber approach", Proc. SPIE 1420, Optical Fibers in Medicine VI, (1 July 1991); https://doi.org/10.1117/12.43860

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KEYWORDS

Optical fibers

Sensors

Signal detection

Luminescence

Optical fiber cables

Signal attenuation

Diodes

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