Endoscopic tissue autofluorescence measurements in the upper aerodigestive tract and the bronchi

Daniel Braichotte; Georges A. Wagnieres; Philippe Monnier; Jean-Francois Savary; Roland Bays; Hubert van den Bergh; Andre Chatelain

doi:10.1117/12.48222

1 November 1991 Endoscopic tissue autofluorescence measurements in the upper aerodigestive tract and the bronchi

Daniel Braichotte, Georges A. Wagnieres, Philippe Monnier, Jean-Francois Savary, Roland Bays, Hubert van den Bergh, Andre Chatelain

Author Affiliations +

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48222
Event: MedTech '91, 1991, Berlin, Germany

Abstract

A single multimode optical fiber is used to excite and collect tissue autofluorescence as well as the fluorescence of an IV-injected fluorescent tumor marker. Measurements of the relative fluorescence intensity of a tumor marker as a function of the time after IV injection permit measurement of the kinetics of this substance in tumor, normal tissue, and skin. The authors believe that these are the first measurements of this kind in patients. Furthermore, the autofluorescence spectrum generated at several excitation wavelengths in different tissues is compared, for instance in the oesophagus, the bronchi, and the tongue. The measuring system is based on an optical multichannel analyzer which measures the fluorescence excited by monochromatic radiation from a spectrally filtered Xe lamp. A correlation between the observed pharmacokinetics and tumor properties like the degree of vascularization is of fundamental importance for each selected tumor marker. Also, the results of these measurements are used for the optical detection of tumors.

Citation Download Citation

Daniel Braichotte, Georges A. Wagnieres, Philippe Monnier, Jean-Francois Savary, Roland Bays, Hubert van den Bergh, and Andre Chatelain "Endoscopic tissue autofluorescence measurements in the upper aerodigestive tract and the bronchi", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48222

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available