Early diagnosis of substance-specific alterations in primary open-angle glaucoma by means of fundus spectrometry

Dietrich Schweitzer; Mateusz Scibor; Martin Hammer; Sabine Guenther

doi:10.1117/12.147532

24 June 1993 Early diagnosis of substance-specific alterations in primary open-angle glaucoma by means of fundus spectrometry

Dietrich Schweitzer, Mateusz Scibor, Martin Hammer, Sabine Guenther

Author Affiliations +

Proceedings Volume 1877, Ophthalmic Technologies III; (1993) https://doi.org/10.1117/12.147532
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

A double beam spectrometer, which works in single photon counting technique, was developed for measuring the reflectance spectra at selected fundus sites in a wavelength range from 430 to 700 nm. By forming logarithmic difference spectra between the reflectance of the normal fundus and the fundus reflectance in different stages of glaucoma only substance or structure specific glaucomatous alterations appear. The approximation of logarithmic difference spectra is demonstrated by a linear model. The primary information in the modelling is only the relative spectral course of important fundus substances like oxyhemoglobin, melanin and xanthophyll. The influence of scattering is formulated as a wavelength-independent intensity, multiplied by a term, containing a power of the wavelength. Found by the spectra-deconvolution, a lack of oxyhemoglobin in the papillo-macular bundle is the first sign of a damaged microcirculation in case of relative losses of the visual field function. The reduced scattering intensity and the altered scattering exponent point to a thinning of the nerve fiber layer.

Citation Download Citation

Dietrich Schweitzer, Mateusz Scibor, Martin Hammer, and Sabine Guenther "Early diagnosis of substance-specific alterations in primary open-angle glaucoma by means of fundus spectrometry", Proc. SPIE 1877, Ophthalmic Technologies III, (24 June 1993); https://doi.org/10.1117/12.147532

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