Time-dependent photon migration imaging in two dimensions: a method for detection and localization of absorbers in tissuelike media

Eva Marie Sevick-Muraca; Joan K. Frisoli; Christina L. Hutchinson; Henryk Szmacinski; Kazimierz Nowaczyk; Michael L. Johnson; Joseph R. Lakowicz

doi:10.1117/12.154662

14 September 1993 Time-dependent photon migration imaging in two dimensions: a method for detection and localization of absorbers in tissuelike media

Eva Marie Sevick-Muraca, Joan K. Frisoli, Christina L. Hutchinson, Henryk Szmacinski, Kazimierz Nowaczyk, Michael L. Johnson, Joseph R. Lakowicz

Author Affiliations +

Proceedings Volume 1888, Photon Migration and Imaging in Random Media and Tissues; (1993) https://doi.org/10.1117/12.154662
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Measurements of time-dependent photon migration appear to provide more information for biomedical optical image reconstruction than continuous wave measurements. Yet the ultimate success of photon migration imaging (PMI) for biomedical optical tomography depends upon developing a method which can rapidly measure `time-of-flight' information, and, in near-real time, extract important information required for image reconstruction. Image reconstruction requires information to (1) detect, (2) locate the position and volume, and (3) characterize the optical properties of an optical heterogeneity that would otherwise be obscured by tissue-like scattering. In this presentation, we report PMI `images' of an obscured absorber obtained from two-dimensional time-dependent photon migration measurements which arise from single point source illumination of a scattering medium with modulated light. These PMI `images' along with a theoretical basis for PMI, suggest the potential to rapidly detect and locate the three- dimensional position of an absorber from two-dimensional frequency-domain measurements of phase, (Theta) ((rho) ,f), and modulation, M((rho) ,f). Independent single-pixel measurements and Monte Carlo simulations of (Theta) ((rho) ,f) and M((rho) ,f) confirm the PMI `images' and the hypothesis for PMI.

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Eva Marie Sevick-Muraca, Joan K. Frisoli, Christina L. Hutchinson, Henryk Szmacinski, Kazimierz Nowaczyk, Michael L. Johnson, and Joseph R. Lakowicz "Time-dependent photon migration imaging in two dimensions: a method for detection and localization of absorbers in tissuelike media", Proc. SPIE 1888, Photon Migration and Imaging in Random Media and Tissues, (14 September 1993); https://doi.org/10.1117/12.154662

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