Efficiency of photodynamic therapy under pulsed laser radiation: model investigations

Valentinas Mickunaitis; Ricardas Rotomskis

doi:10.1117/12.168696

1 March 1994 Efficiency of photodynamic therapy under pulsed laser radiation: model investigations

Valentinas Mickunaitis, Ricardas Rotomskis

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168696
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Photochemical reactions under the action of powerful ultrashort laser pulses occur with excitation of sensitizers to high lying singlet and triplet states can be quite different from those occurring from S₁ and T₁ and in some cases have greater photochemical and photobiological efficiency in vivo and in vitro. In our paper we are modelling the primary photoprocesses in hematoporphyrin molecules under the excitation by cw and pulsed light. On the basis of the proposed theoretical model the pulse duration and intensity region, where photobleaching of ground state absorption and absorption from exited singlet and triplet states have influence on the type II photodynamic processes, was estimated. The results show that Hp ground state bleaching and the efficiency of photodynamic therapy is reduced when the pulse energy is over the value 10 mJ/cm². The dependence of the efficiency of the photochemistry from triplet state on laser pulse intensity and duration was studied. The published results of some PDT experiments in comparison with efficiency curve based on our model are presented.

Citation Download Citation

Valentinas Mickunaitis and Ricardas Rotomskis "Efficiency of photodynamic therapy under pulsed laser radiation: model investigations", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168696

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