Photochemical inactivation of viruses by antibody conjugates of compounds generating singlet oxygen

Alexander P. Savitsky; Andrey I. Tourkin; Elena V. Tourkina; Tatyana V. Cherednikova; Gely V. Ponomarev; Boris F. Poglazov

doi:10.1117/12.168670

1 March 1994 Photochemical inactivation of viruses by antibody conjugates of compounds generating singlet oxygen

Alexander P. Savitsky, Andrey I. Tourkin, Elena V. Tourkina, Tatyana V. Cherednikova, Gely V. Ponomarev, Boris F. Poglazov

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168670
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

For the first time a method is proposed for targeted destruction of viral particles with a photoimmuno-toxin. The photoinununotoxin is a conjugate of antibodies and dimethoxy haematoporphyrin (a potent singlet oxygen generator), binding with the viral particle and upon illumination with visible light inactivating the virus by singlet oxygen. The method can be used to combat viral infection in humans and to prevent lysis of industrial micro-organisms by lysogenic bacteriophage strains.

Citation Download Citation

Alexander P. Savitsky, Andrey I. Tourkin, Elena V. Tourkina, Tatyana V. Cherednikova, Gely V. Ponomarev, and Boris F. Poglazov "Photochemical inactivation of viruses by antibody conjugates of compounds generating singlet oxygen", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168670

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available