Distinctive role of activated tumor-associated macrophages in photosensitizer accumulation

Mladen Korbelik; Gorazd Krosl

doi:10.1117/12.208181

1 May 1995 Distinctive role of activated tumor-associated macrophages in photosensitizer accumulation

Mladen Korbelik, Gorazd Krosl

Proceedings Volume 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV; (1995) https://doi.org/10.1117/12.208181
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Cells dissociated from tumors (carcinomas and sarcomas) growing subcutaneously in mice that have been administered Photofrin or other photosensitizers were analyzed by flow cytometry. Monoclonal antibodies were used for identification of major cellular populations contained in these tumors. The results demonstrate that a subpopulation of tumor-associated macrophages (TAMs) is unique among tumor cell populations in that it excels in the accumulation of very high levels of photosensitizers. These macrophages showed an increased expression of interleukin 2 receptor, which is indicative of their activated state. since macrophages were reported to concentrate in the periphery of human neoplasms, it is suggested that activates TAMs are the determinants of tumor-localized photosensitizer fluorescence.

Citation Download Citation

Mladen Korbelik and Gorazd Krosl "Distinctive role of activated tumor-associated macrophages in photosensitizer accumulation", Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208181

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