Laser-induced fluorescence spectroscopy of AlPc4 and liposomal ZnPc in a rat bladder tumor model and correlation with PDT efficiency

N. J. Edinak; Angelika C. Rueck; Rudolf W. Steiner; Felicitas Genze; Victor B. Loschenov

doi:10.1117/12.260778

4 December 1996 Laser-induced fluorescence spectroscopy of AlPc4 and liposomal ZnPc in a rat bladder tumor model and correlation with PDT efficiency

N. J. Edinak, Angelika C. Rueck, Rudolf W. Steiner, Felicitas Genze, Victor B. Loschenov

Author Affiliations +

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260778
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

The problem of opportune diagnostic and treatment modalities is very actual. In recent years special attention has been paid to the development of new methods for the diagnostic of tumor spreading. That allows a physician to determine the method of further therapy. The success of PDT is defined by available accumulation of the PS in tumor tissue, therefore the photosensitizer concentration control determines the efficacy of the therapy. The methods that allow accumulation of PS in the therapeutic dose allowed us to perform PDT with smaller administration dose and avoid the complications of photosensitivity. The preliminary results of using ZnPc and AlPc in the rats show that we can reduce the dose of the drug with the increasing of the efficacy of the treatment simultaneously, if we use the PS under the control of the accumulation for the best contrast between normal and tumor tissue and try to apply methods of treatment which allow us to receive more oxygenation and using the affect of more accumulation of the drug after preliminary laser stimulation.

Citation Download Citation

N. J. Edinak, Angelika C. Rueck, Rudolf W. Steiner, Felicitas Genze, and Victor B. Loschenov "Laser-induced fluorescence spectroscopy of AlPc4 and liposomal ZnPc in a rat bladder tumor model and correlation with PDT efficiency", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260778

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available