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27 April 2016 Intraoperative detection and elimination of microscopic tumors in head and neck (Conference Presentation)
Ekaterina Y. Lukianova-Hleb, Yoo-Shin Kim, Ihar Belatsarkouski, Ehab Y. Hanna, Ann M. Gillenwater, Brian O'Neill, Dmitri Lapotko
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Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 96891Y (2016) https://doi.org/10.1117/12.2217942
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
Failure of cancer surgery to intraoperatively detect and eliminate microscopic residual disease (MRD) causes lethal recurrence and metastases, whereas removal of important normal tissues causes excessive morbidity. We report plasmonic nanobubble (PNB) surgical technology to intraoperatively detect and eliminate MRD in surgical bed. PNBs were generated in vivo in head and neck cancer cells by systemically targeting tumor with gold colloids and locally-applied near-infrared low energy short laser pulse, and were simultaneously detected with acoustic probe. In mouse models of head and neck squamous cell carcinoma, single cancer cells and MRD (undetectable with standard histological methods) were instantaneously non-invasively detected in solid tissue in surgical bed. In resectable MRD, PNB-guided surgery prevented local recurrence and delivered 100% tumor-free survival. In unresectable MRD, PNB nano-surgery improved survival by two-fold compared to standard surgery. PNB metrics correlated with the tumor recurrence rate. PNB surgical technology precisely detects and immediately eliminates MRD at macro- and micro-scale in a simple and safe intraoperative procedure.
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Ekaterina Y. Lukianova-Hleb, Yoo-Shin Kim, Ihar Belatsarkouski, Ehab Y. Hanna, Ann M. Gillenwater, Brian O'Neill, and Dmitri Lapotko "Intraoperative detection and elimination of microscopic tumors in head and neck (Conference Presentation)", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96891Y (27 April 2016); https://doi.org/10.1117/12.2217942
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KEYWORDS
Tumors
Cancer
Head
Neck
Surgery
Standards development
Tissues
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