In-vivo photodynamic activity of mTHPC poly(ethylene glycol) conjugates (SC102)

Michael F. Grahn; Anita McGuinness; Martin L. de Jode; Andreas Giger; Amarpreet S. Dhiman; Chi-Ming Cheung; Sharon Pavitt; Robin Benzie; Norman S. Williams

doi:10.1117/12.297801

29 December 1997 In-vivo photodynamic activity of mTHPC poly(ethylene glycol) conjugates (SC102)

Michael F. Grahn, Anita McGuinness, Martin L. de Jode, Andreas Giger, Amarpreet S. Dhiman, Chi-Ming Cheung, Sharon Pavitt, Robin Benzie, Norman S. Williams

Author Affiliations +

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297801
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The photosensitizer m-THPC (temoporfin, Foscan^R) is probably the most potent compound currently being tested for clinical use in photodynamic therapy. However, this compound is not freely water soluble and is extensively taken up and excreted by the liver following injection. This paper describes the initial characterization of a group of water- soluble poly(ethylene glycol) conjugates of m-THPC (SC102) in a mouse model system. The use of a carbonate linking group results in a labile compound which produced very high systemic photosensitivity at early times after injection. Triazine linked conjugates were stable both in vitro and in vivo and, although less potent than m-THPC on a molar basis, were capable of producing equivalent tumor necrosis accompanied by relatively low levels of muscle damage. In addition, SC102 tumor necrosis was seen over a wide range of drug-light intervals suggesting that these compounds may be less sensitive to treatment conditions than is m-THPC.

Citation Download Citation

Michael F. Grahn, Anita McGuinness, Martin L. de Jode, Andreas Giger, Amarpreet S. Dhiman, Chi-Ming Cheung, Sharon Pavitt, Robin Benzie, and Norman S. Williams "In-vivo photodynamic activity of mTHPC poly(ethylene glycol) conjugates (SC102)", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297801

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