Imaging the primate retina using polarization-sensitve optical coherence tomography

Jason D. Marsack; Mathieu G. Ducros; Sapun H. Parekh; Sharon L. Thomsen M.D.; Henry Grady Rylander III; Thomas E. Milner

doi:10.1117/12.429286

7 June 2001 Imaging the primate retina using polarization-sensitve optical coherence tomography

Jason D. Marsack, Mathieu G. Ducros, Sapun H. Parekh, Sharon L. Thomsen M.D., Henry Grady Rylander III, Thomas E. Milner

Author Affiliations +

Proceedings Volume 4245, Ophthalmic Technologies XI; (2001) https://doi.org/10.1117/12.429286
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We report results of a study using polarization sensitive optical coherence tomography (PSOCT) to measure physical properties of the retina and to create images of retinal microstructure. Our instrument incorporates a mode-locked Ti:Al₂O³ laser and achromatic polarization optics to record high resolution images. High-resolution B scans (two-dimensional images) of the in-vivo rhesus monkey retina have been recorded in the optic disk, peripapillary area and macula. Images of the peripapillary area allow measurement of the retinal nerve fiber layer (RNFL) thickness and calculation of the Stokes parameters of light back-scattered from the retina. Results of our study indicate: 1) PSOCT may be utilized to measure RNFL thickness; 2) PSOCT may be used to measure areas of birefringent tissue in the retina; and 3) selection of a scan pattern surrounding the optic nerve should account for the relatively large radial RNFL thickness gradient. Moreover, since glaucoma manifests in a destruction of the RNFL, PSOCT may be useful as a screening and diagnostic modality.

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Jason D. Marsack, Mathieu G. Ducros, Sapun H. Parekh, Sharon L. Thomsen M.D., Henry Grady Rylander III, and Thomas E. Milner "Imaging the primate retina using polarization-sensitve optical coherence tomography", Proc. SPIE 4245, Ophthalmic Technologies XI, (7 June 2001); https://doi.org/10.1117/12.429286

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