Quantitation of tissue properties in small volumes

Judith R. Mourant; Tamara M. Johnson; James P. Freyer

doi:10.1117/12.434497

29 June 2001 Quantitation of tissue properties in small volumes

Judith R. Mourant, Tamara M. Johnson, James P. Freyer

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434497
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The quantification of tissue properties by optical measurements will facilitate the development of noninvasive methods of cancer diagnosis and detection. Optical measurements are sensitive to tissue structure which is known to change during tumorigenesis. The goals of the work presented in this paper were to verify that the primary scatterers of light in cells are structures much smaller than the nucleus and then to develop an optical technique that can quantify parameters of structures the same size as the scattering features in cells. Polarized, elastic back-scattering was found to be able to quantify changes in scattering properties for turbid media consisting of scatterers of the size found in tissue.

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Judith R. Mourant, Tamara M. Johnson, and James P. Freyer "Quantitation of tissue properties in small volumes", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434497

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KEYWORDS

Light scattering

Scattering

Tissue optics

Tissues

Optical testing

Polarization

Optical spheres

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