Development and use of a confocal microendoscope for in-vivo histopathologic diagnosis

Arthur F. Gmitro; Andrew R. Rouse

doi:10.1117/12.427944

4 June 2001 Development and use of a confocal microendoscope for in-vivo histopathologic diagnosis

Arthur F. Gmitro, Andrew R. Rouse

Proceedings Volume 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III; (2001) https://doi.org/10.1117/12.427944
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A confocal microendoscope for in vivo imaging at the cellular level has been developed. The system consists of a slit-scanning confocal microscope coupled to a fiber optic imaging bundle with a miniature objective lens and focusing mechanism at the distal tip of the catheter. The system is used primarily for imaging tissue fluorescence--either autofluorescence or fluorescence from an exogenous compound. The microendoscope has a lateral resolution of 2 micrometers allowing visualization of structures at the cellular level, and because it is confocal, it can image at selected depths below the tissue surface. Excellent in vivo imaging results have been obtained in animal models and encouraging ex vivo results have been achieved with human tissue.

Citation Download Citation

Arthur F. Gmitro and Andrew R. Rouse "Development and use of a confocal microendoscope for in-vivo histopathologic diagnosis", Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); https://doi.org/10.1117/12.427944

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