In vivo optical imaging of cortical spreading depression in rat

Shangbin Chen; Pengcheng Li; Weihua Luo; Hui Gong; Haiying Cheng; Qingming Luo

doi:10.1117/12.546172

8 December 2003 In vivo optical imaging of cortical spreading depression in rat

Shangbin Chen, Pengcheng Li, Weihua Luo, Hui Gong, Haiying Cheng, Qingming Luo

Proceedings Volume 5254, Third International Conference on Photonics and Imaging in Biology and Medicine; (2003) https://doi.org/10.1117/12.546172
Event: Third International Conference on Photonics and Imaging in Biology and Medicine, 2003, Wuhan, China

Abstract

Intrinsic optical signals imaging (IOSI) and laser speckle imaging (LSI) are both novel techniques for functional neuroimaging in vivo. Combining them to study cortical spreading depression (CSD) which is an important disease model for migraine and other neurological disorders. CSD were induced by pinprick in Sprague-Dawley rats. Intrinsic optical signals (IOS) at 540 nm showed CSD evolution happened in one hemisphere cortex at speeds of 3.7^±0.4 mm/min, and the vasodilation closely correlated a four-phasic response. By LSI, we observed a transient and significant increase cerebral blood flow (CBF). In this paper, optical imaging would be showed as a powerful tool for describing the hemodynamic character during CSD in rat.

Citation Download Citation

Shangbin Chen, Pengcheng Li, Weihua Luo, Hui Gong, Haiying Cheng, and Qingming Luo "In vivo optical imaging of cortical spreading depression in rat", Proc. SPIE 5254, Third International Conference on Photonics and Imaging in Biology and Medicine, (8 December 2003); https://doi.org/10.1117/12.546172

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