Separation of blood cells and plasma in microchannel bend structures

Christoph Blattert; Reinhold Jurischka; Andreas Schoth; Paul Kerth; Wolfgang Menz

doi:10.1117/12.568823

8 December 2004 Separation of blood cells and plasma in microchannel bend structures

Christoph Blattert, Reinhold Jurischka, Andreas Schoth, Paul Kerth, Wolfgang Menz

Proceedings Volume 5591, Lab-on-a-Chip: Platforms, Devices, and Applications; (2004) https://doi.org/10.1117/12.568823
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

Biological applications of micro assay devices require easy implementable on-chip microfluidics for separation of plasma or serum from blood. This is achieved by a new blood separation technique based on a microchannel bend structure developed within the collaborative Micro-Tele-BioChip (μTBC) project. Different prototype polymer chips have been manufactured with an UV-LIGA process and hot embossing technology. The separation mechanisms have been identified and the separation efficiency of these chips has been determined by experimental measurements using human blood samples. Results show different separation efficiencies for cells and plasma up to 100 % depending on microchannel geometry, hematocrit, and feed velocity. This novel technique leads to an alternative blood separation method as compared to existing micro separation technologies.

Citation Download Citation

Christoph Blattert, Reinhold Jurischka, Andreas Schoth, Paul Kerth, and Wolfgang Menz "Separation of blood cells and plasma in microchannel bend structures", Proc. SPIE 5591, Lab-on-a-Chip: Platforms, Devices, and Applications, (8 December 2004); https://doi.org/10.1117/12.568823

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available