Laser speckle techniques for studying thermally induced dynamics of blood perfusion of mice's mesentery

Dan Zhu; Yang Weng; Ting Zhang; Qian Liu; Qingming Luo

doi:10.1117/12.696925

21 July 2006 Laser speckle techniques for studying thermally induced dynamics of blood perfusion of mice's mesentery

Dan Zhu, Yang Weng, Ting Zhang, Qian Liu, Qingming Luo

Proceedings Volume 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII; 616302 (2006) https://doi.org/10.1117/12.696925
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation

Abstract

Measurement of blood perfusion has been playing an important role in the field of bioheat transfer and clinical thermotherapy. However, it is not easy to gain thermal induced dynamics of blood perfusion of local tissue. Laser speckle techniques we developed were valid. In this paper, we reviewed our progress on studying thermal induced dynamics of blood perfusion of mice's mesentery with laser speckle techniques which included laser speckle microscopy with CCD camera for isolate vessel and laser speckle imaging for local vessels of mesentery of mice. The principles of the two kinds of laser speckle techniques were introduced briefly. The blood perfusion of normal and tumor mice's mesentery were showed during different constant temperatures (41-45°C) by laser speckle imaging technique. Further more, the dynamics of velocity, diameter and blood perfusion for normal and tumor were compared. The results showed that tumor was more sensitive to heat than normal tissue, which accorded with pathological investigation. Finally, the quantitative relationship among the blood perfusion, the temperature-dependent and the damage-dependent was established. The model could describe successfully thermal induced dynamics of blood perfusion of mesentery for both normal and tumor mice.

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Dan Zhu, Yang Weng, Ting Zhang, Qian Liu, and Qingming Luo "Laser speckle techniques for studying thermally induced dynamics of blood perfusion of mice's mesentery", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616302 (21 July 2006); https://doi.org/10.1117/12.696925

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KEYWORDS

Blood

Speckle

Tumors

Blood circulation

Laser speckle imaging

Microscopy

Temperature metrology

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