Approach of trans-rectal NIR optical tomography probing for the imaging of prostate with trans-rectal ultrasound correlation

Daqing Piao; Zhen Jiang; Guan Xu; Cameron Musgrove; Charles F. Bunting

doi:10.1117/12.778329

20 February 2008 Approach of trans-rectal NIR optical tomography probing for the imaging of prostate with trans-rectal ultrasound correlation

Daqing Piao, Zhen Jiang, Guan Xu, Cameron Musgrove, Charles F. Bunting

Author Affiliations +

Proceedings Volume 6850, Multimodal Biomedical Imaging III; 68500E (2008) https://doi.org/10.1117/12.778329
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The trans-rectal implementation of NIR optical tomography makes it possible to assess functional status like hemoglobin concentration and oxygen saturation in prostate non-invasively. Trans-rectal NIR tomography may provide tissue-specific functional contrast that is potentially valuable for differentiation of cancerous lesions from normal tissues. Such information will help to determine if a prostate biopsy is needed or can be excluded for an otherwise ambiguous lesion. The relatively low spatial resolution due to the diffuse light detection in trans-rectal NIR tomography, however, limits the accuracy of localizing a suspicious tissue volume. Trans-rectal ultrasound (TRUS) is the clinical standard for guiding the positioning of biopsy needle owing to its resolution and convenience; nevertheless, TRUS lacks the pathognomic specificity to guide biopsy to only the suspicious lesions. The combination of trans-rectal NIR tomography with TRUS could potentially give better differentiation of cancerous tissue from normal background and to accurately localize the cancer-suspicious contrast obtained from NIR tomography. This paper will demonstrate the design and initial evaluation of a trans-rectal NIR tomography probe that can conveniently integrate with a commercial TRUS transducer. The transrectal NIR tomography obtained from this probe is concurrent with TRUS at matching sagittal imaging plane. This design provides the flexibility of simple correlation of trans-rectal NIR with TRUS, and using TRUS anatomic information as spatial prior for NIR image reconstruction.

Citation Download Citation

Daqing Piao, Zhen Jiang, Guan Xu, Cameron Musgrove, and Charles F. Bunting "Approach of trans-rectal NIR optical tomography probing for the imaging of prostate with trans-rectal ultrasound correlation", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500E (20 February 2008); https://doi.org/10.1117/12.778329

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