Investigating the effects of Panadol on mouse liver by in vivo multiphoton microscopy

Feng Chieh Li; Huei Liang Jr.; Shu-Mei Yang; Hsuan-Shu Lee; Chen-Yuan Dong

doi:10.1117/12.763367

12 March 2008 Investigating the effects of Panadol on mouse liver by in vivo multiphoton microscopy

Feng Chieh Li, Huei Liang Jr., Shu-Mei Yang, Hsuan-Shu Lee, Chen-Yuan Dong

Proceedings Volume 6860, Multiphoton Microscopy in the Biomedical Sciences VIII; 68601Y (2008) https://doi.org/10.1117/12.763367
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Conventional hepatic research relies heavily on histological images for obtaining morphological information of the liver. However, static histological images can not provide real-time dynamic information of in vivo physiological processes such as cellular motion or damage. For a long time, panadol has been used in pain relief. However, Panadol may have unwanted side effects and detailed information of the effects of Panadol on hepatic metabolism is unknown. In this work, we developed a high resolution intravital hepatic imaging chamber to study the effects of Panadol on liver. We expect this methodology to be useful in revealing the detailed metabolism of liver after using Panadol and this approach allows us to achieve a better understanding of hepatic processes. In our approach, we use multiphoton fluorescence (MPF) microscopy to observe the side effect of liver on using Panadol inside the in vivo mouse animal model.

Citation Download Citation

Feng Chieh Li, Huei Liang Jr., Shu-Mei Yang, Hsuan-Shu Lee, and Chen-Yuan Dong "Investigating the effects of Panadol on mouse liver by in vivo multiphoton microscopy", Proc. SPIE 6860, Multiphoton Microscopy in the Biomedical Sciences VIII, 68601Y (12 March 2008); https://doi.org/10.1117/12.763367

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