Reconstruction of hemodynamics and sensitizer distributions during interstitial PDT using spectroscopy with linear light sources

Jarod C. Finlay; Ken Wang; Yida Hu; Timothy C. Zhu

doi:10.1117/12.822964

13 July 2009 Reconstruction of hemodynamics and sensitizer distributions during interstitial PDT using spectroscopy with linear light sources

Jarod C. Finlay, Ken Wang, Yida Hu, Timothy C. Zhu

Author Affiliations +

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738044 (2009) https://doi.org/10.1117/12.822964
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Light dosimetry for photodynamic therapy requires a knowledge of the optical absorption spectrum of the tissue being treated Here, we present a theoretical and experimental analysis of the capabilities of a system using interstitial linear light sources ranging in length from 2 to 5 cm to illuminate the tissue interstitially, and isotropic point-like detectors to measure the resulting diffusely transmitted light. The sources and detectors are translated in transparent plastic catheters under the control of a motorized positioning system designed for interstitial measurements in the prostate. The light source is a quartz-tungsten-halogen (QTH), and the spectrally resolved detection is accomplished using a CCD-based grating spectrometer. The data are analyzed using an approximation to the radiative transport equation, assuming homogeneous scattering and heterogeneous absorption spectra Absorption spectra are reconstructed independently for individual source-detector channel pairs. Sequential reconstruction can then be used to create a 3-dimensional reconstruction. The results of simulated data, measurements made in multi-component phantoms, and synthetic data reconstructed from in vivo measurements made with point sources demonstrate the feasibility of this method.

Citation Download Citation

Jarod C. Finlay, Ken Wang, Yida Hu, and Timothy C. Zhu "Reconstruction of hemodynamics and sensitizer distributions during interstitial PDT using spectroscopy with linear light sources", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738044 (13 July 2009); https://doi.org/10.1117/12.822964

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