Optical modulation of smooth muscle cell contraction

Jonghee Yoon; Myunghwan Choi; Chulhee Choi

doi:10.1117/12.841871

25 February 2010 Optical modulation of smooth muscle cell contraction

Jonghee Yoon, Myunghwan Choi, Chulhee Choi

Proceedings Volume 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII; 75681X (2010) https://doi.org/10.1117/12.841871
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Even though electrical stimulation is generally used for induction of smooth muscle cell contraction, it is very hard to obtain fine control and also very invasive for inserting electrodes. Herein, we developed a new optical technology to control smooth muscle cell contraction. This optical method using femtosecond pulsed laser (FSPL) has advantage of focused stimulation and fine control of stimulation intensity. Upon brief exposure to FSPL, smooth muscle cells showed a rapid increase of intracellular calcium levels followed by cell contraction. Collectively, we suggest that FSPL can be a useful tool for control of smooth muscle cell contraction.

Citation Download Citation

Jonghee Yoon, Myunghwan Choi, and Chulhee Choi "Optical modulation of smooth muscle cell contraction", Proc. SPIE 7568, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VIII, 75681X (25 February 2010); https://doi.org/10.1117/12.841871

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