Current developments in clinical multiphoton tomography

Karsten König; Martin Weinigel; Hans Georg Breunig; Axel Gregory; Peter Fischer; Marcel Kellner-Höfer; Rainer Bückle

doi:10.1117/12.843117

26 February 2010 Current developments in clinical multiphoton tomography

Karsten König, Martin Weinigel, Hans Georg Breunig, Axel Gregory, Peter Fischer, Marcel Kellner-Höfer, Rainer Bückle

Proceedings Volume 7569, Multiphoton Microscopy in the Biomedical Sciences X; 756915 (2010) https://doi.org/10.1117/12.843117
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Two-photon microscopy has been introduced in 1990 [1]. 13 years later, CE-marked clinical multiphoton systems for 3D imaging of human skin with subcellular resolution have been launched by the JenLab company with the tomograph DermaInspect^TM. In 2010, the second generation of clinical multiphoton tomographs was introduced. The novel mobile multiphoton tomograph MPTflex^TM, equipped with a flexible articulated optical arm, provides an increased flexibility and accessibility especially for clinical and cosmetical examinations. The multiphoton excitation of fluorescent biomolecules like NAD(P)H, flavins, porphyrins, elastin, and melanin as well as the second harmonic generation of collagen is induced by picojoule femtosecond laser pulses from an tunable turn-key near infrared laser system. The ability for rapid highquality image acquisition, the user-friendly operation of the system, and the compact and flexible design qualifies this system to be used for melanoma detection, diagnostics of dermatological disorders, cosmetic research, and skin aging measurements as well as in situ drug monitoring and animal research. So far, more than 1,000 patients and volunteers have been investigated with the multiphoton tomographs in Europe, Asia, and Australia.

Citation Download Citation

Karsten König, Martin Weinigel, Hans Georg Breunig, Axel Gregory, Peter Fischer, Marcel Kellner-Höfer, and Rainer Bückle "Current developments in clinical multiphoton tomography", Proc. SPIE 7569, Multiphoton Microscopy in the Biomedical Sciences X, 756915 (26 February 2010); https://doi.org/10.1117/12.843117

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