Enhanced transfection of brain tumor suppressor genes by photochemical internalization

Chih H. Chou; Chung-Ho Sun; Yi-Hong Zhou; Steen J. Madsen; Henry Hirschberg

doi:10.1117/12.882954

17 February 2011 Enhanced transfection of brain tumor suppressor genes by photochemical internalization

Chih H. Chou, Chung-Ho Sun, Yi-Hong Zhou, Steen J. Madsen, Henry Hirschberg

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78832D (2011) https://doi.org/10.1117/12.882954
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

One of many limitations for cancer gene therapy is the inability of the therapeutic gene to transfect a sufficient number of tumor cells. Photochemical internalization (PCI) is a photodynamic therapy-based approach for improving the delivery of macromolecules and genes into the cell cytosol. The utility of PCI for the delivery of a tumor suppressor gene (PAX-6) was investigated in monolayers and spheroids consisting of F98 rat glioma cells.

Citation Download Citation

Chih H. Chou, Chung-Ho Sun, Yi-Hong Zhou, Steen J. Madsen, and Henry Hirschberg "Enhanced transfection of brain tumor suppressor genes by photochemical internalization", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832D (17 February 2011); https://doi.org/10.1117/12.882954

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available