A hybrid approach combining microCT and fluorescence tomography: imaging workflow and system of coordinate registration

Robert Holt; Fadi El-Ghussein; Kenneth M. Tichauer; Frederic Leblond; Brian W. Pogue

doi:10.1117/12.881449

10 February 2011 A hybrid approach combining microCT and fluorescence tomography: imaging workflow and system of coordinate registration

Robert Holt, Fadi El-Ghussein, Kenneth M. Tichauer, Frederic Leblond, Brian W. Pogue

Author Affiliations +

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 789213 (2011) https://doi.org/10.1117/12.881449
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

A fluorescence imaging system was designed to interface with a microCT device. We focus on refining the workflow for meshing and the coordinate registration of the two systems. The former is performed by projection imaging in the microCT, reconstructing a volume, segmenting using image processing software, and meshing using the NIRFAST software. The coordinate registration is performed by exploiting the geometry of the fluorescence system. We determine the location of the geometrical center of a subject, which can be used to derive a translation between instruments. The co-registration is validated by imaging optical phantoms.

Citation Download Citation

Robert Holt, Fadi El-Ghussein, Kenneth M. Tichauer, Frederic Leblond, and Brian W. Pogue "A hybrid approach combining microCT and fluorescence tomography: imaging workflow and system of coordinate registration", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 789213 (10 February 2011); https://doi.org/10.1117/12.881449

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