Optical control of urinary bladder contraction using femtosecond-pulsed laser

Jonghee Yoon; Myunghwan Choi; Chulhee Choi

doi:10.1117/12.874022

18 February 2011 Optical control of urinary bladder contraction using femtosecond-pulsed laser

Jonghee Yoon, Myunghwan Choi, Chulhee Choi

Proceedings Volume 7897, Optical Interactions with Tissue and Cells XXII; 789714 (2011) https://doi.org/10.1117/12.874022
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Even though catheterization or electric stimulation are used for treatment of neurogenic bladder, invasiveness and inconvenience of these approaches prompt us to develop a new possible therapeutic method to control urination by using optical stimulation. The optical method using femtosecond pulsed laser (FSPL) has advantages of focused and subsurface stimulation. Irradiation of FSPL induced a rapid increase of intracellular calcium level followed by contraction of primary cultured human bladder smooth muscle cells. Short exposure of bladder detrusor ex-vivo to FSPL also induced a controlled contraction of detrusor. Collectively, we propose that FSPL can be considered as a potential therapeutic approach for intractable neurogenic bladder.

Citation Download Citation

Jonghee Yoon, Myunghwan Choi, and Chulhee Choi "Optical control of urinary bladder contraction using femtosecond-pulsed laser", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 789714 (18 February 2011); https://doi.org/10.1117/12.874022

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