Synthesis and characterization of fluorescent dyes-magnetic nanoparticles for bioimaging applications

Swee Kuan Yen; Dominik Jańczewski; Surani Bin Dolmanan; Tripathy Sudhiranjan; Subramanian Tamil Selvan

doi:10.1117/12.917325

2 February 2012 Synthesis and characterization of fluorescent dyes-magnetic nanoparticles for bioimaging applications

Swee Kuan Yen, Dominik Jańczewski, Surani Bin Dolmanan, Tripathy Sudhiranjan, Subramanian Tamil Selvan

Proceedings Volume 8232, Colloidal Nanocrystals for Biomedical Applications VII; 82320L (2012) https://doi.org/10.1117/12.917325
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Magnetic-fluorescent nanoparticles have been emerging as potential bimodal probes in the area of bioimaging. However, near-infrared (NIR) fluorescent dye as a fluorescent material for bimodal probe remains unexplored. The tailor-design of NIR cyanine dye is challenging. Herein, we report the synthesis and characterization of novel functional IR 820 dye. This modified IR 820 has been successfully conjugated with long and short back-bone chain polymers. All these compounds preserve good water solubility and photochemical properties. The magnetic-fluorescent bimodal probe has been demonstrated, wherein the magnetic nanoparticles have been coated with dye-polymer. The cytotoxicity studies on HeLa cells show that MNP@dye-polymer with short back-bone chain has better cell viability.

Citation Download Citation

Swee Kuan Yen, Dominik Jańczewski, Surani Bin Dolmanan, Tripathy Sudhiranjan, and Subramanian Tamil Selvan "Synthesis and characterization of fluorescent dyes-magnetic nanoparticles for bioimaging applications", Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320L (2 February 2012); https://doi.org/10.1117/12.917325

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